Direct spectrophotometric measurement of supra-physiological levels of ascorbate in plasma

Background: Supra-physiological concentrations of ascorbate, vitamin C, in blood, greater than 1 mM, achieved through intravenous administration (IV), are being tested in clinical trials to treat human disease, e.g. cancer. These trials need information on the high levels of ascorbate achieved in bl...

Full description

Bibliographic Details
Main Authors: Jordan R. Witmer, Bailey J. Wetherell, Brett A. Wagner, Juan Du, Joseph J. Cullen, Garry R. Buettner
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300155