Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

Abstract Objectives In this study, we investigated the possible analgesic effects of Botulinum toxin type A (BoNT/A) on trigeminal neuralgia (TN). A modified TN mouse model was established by chronic constriction injury of the distal infraorbital nerve (dIoN-CCI) in mice, and the possible roles of m...

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Bibliographic Details
Main Authors: Wei-Jia Chen, Jing-Qi Niu, Yi-Ting Chen, Wen-Jing Deng, Ying-Ying Xu, Jing Liu, Wei-Feng Luo, Tong Liu
Format: Article
Language:English
Published: BMC 2021-05-01
Series:The Journal of Headache and Pain
Subjects:
Trigeminal neuralgia
Anxiety
Microglia
Innate immunity
Toll-like receptor 2 (TLR2)
Botulinum toxin type A
Online Access:https://doi.org/10.1186/s10194-021-01254-2

Internet

https://doi.org/10.1186/s10194-021-01254-2

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