Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment

Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment

Abstract Background The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous and endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes and oxidative stress, and chemoresistant cancer cells express high levels of ALDH enz...

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Bibliographic Details
Main Authors: Jeewon Kim, Che-Hong Chen, Jieying Yang, Daria Mochly-Rosen
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Biomedical Science
Subjects:
Aldehyde dehydrogenase
Cisplatin and Reactive Oxygen Species
Online Access:http://link.springer.com/article/10.1186/s12929-017-0338-8

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http://link.springer.com/article/10.1186/s12929-017-0338-8

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