Kinetic Constraints in the Specific Interaction between Phosphorylated Ubiquitin and Proteasomal Shuttle Factors

Kinetic Constraints in the Specific Interaction between Phosphorylated Ubiquitin and Proteasomal Shuttle Factors

Ubiquitin (Ub) specifically interacts with the Ub-associating domain (<i>UBA</i>) in a proteasomal shuttle factor, while the latter is involved in either proteasomal targeting or self-assembly coacervation. PINK1 <i>phosphorylates Ub</i> at S65 and makes Ub alternate between...

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Bibliographic Details
Main Authors: Ling-Yun Qin, Zhou Gong, Kan Liu, Xu Dong, Chun Tang
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomolecules
Subjects:
protein-protein interaction
ubiquitin
phosphorylation
proteasomal shuttle factor
ubiquitin-associated domain
induced fit
Online Access:https://www.mdpi.com/2218-273X/11/7/1008

Internet

https://www.mdpi.com/2218-273X/11/7/1008

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