Differential role of autophagy in CD4 T cells and macrophages during X4 and R5 HIV-1 infection.

Differential role of autophagy in CD4 T cells and macrophages during X4 and R5 HIV-1 infection.

BACKGROUND: HIV-1 can infect and replicate in both CD4 T cells and macrophages. In these cell types, HIV-1 entry is mediated by the binding of envelope glycoproteins (gp120 and gp41, Env) to the receptor CD4 and a coreceptor, principally CCR5 or CXCR4, depending on the viral strain (R5 or X4, respec...

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Bibliographic Details
Main Authors: Lucile Espert, Mihayl Varbanov, Véronique Robert-Hebmann, Sophie Sagnier, Ian Robbins, Françoise Sanchez, Virginie Lafont, Martine Biard-Piechaczyk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2686268?pdf=render

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http://europepmc.org/articles/PMC2686268?pdf=render

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