MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions

MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions

Abstract scRNA-seq profiles each represent a highly partial sample of mRNA molecules from a unique cell that can never be resampled, and robust analysis must separate the sampling effect from biological variance. We describe a methodology for partitioning scRNA-seq datasets into metacells: disjoint...

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Bibliographic Details
Main Authors: Yael Baran, Akhiad Bercovich, Arnau Sebe-Pedros, Yaniv Lubling, Amir Giladi, Elad Chomsky, Zohar Meir, Michael Hoichman, Aviezer Lifshitz, Amos Tanay
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Genome Biology
Subjects:
RNA-seq
scRNA-seq
Graph partition
Multinomial distribution
Sampling variance
Clustering
Online Access:http://link.springer.com/article/10.1186/s13059-019-1812-2

Internet

http://link.springer.com/article/10.1186/s13059-019-1812-2

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