Synthesis of 2-{[2-(2-oxo-1-azacycloalkyl)acetamido]phenoxy}acetic acids and their activity as aminopeptidase M inhibitors

Synthesis of 2-{[2-(2-oxo-1-azacycloalkyl)acetamido]phenoxy}acetic acids and their activity as aminopeptidase M inhibitors

A series of 9 phenoxyacetic acids substituted in the o-, m-, and p-position of benzene ring with 2-(2-oxo-1-azacycloalkyl)acetamidic moiety containing 5–7-membered w-lactam ring was prepared by a 4-step synthetic pro¬cedure. Five selected substances of this series were tested in vitro for inhibition...

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Bibliographic Details
Main Authors: OLDŘICH FARSA, MILAN DOČKAL, JANA KOVÁČIKOVÁ, MÁRIA BENEŠOVÁ
Format: Article
Language:English
Published: Serbian Chemical Society 2008-08-01
Series:Journal of the Serbian Chemical Society
Subjects:
w-lactams
phenoxyacetic acids
aminopeptidase M
inhibition
Online Access:http://www.shd.org.yu/JSCS/Vol73/No8-9/JSCS-3760.pdf

Internet

http://www.shd.org.yu/JSCS/Vol73/No8-9/JSCS-3760.pdf

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