Caveolin-1 Regulates Chemokine Receptor 5-Mediated Contribution of Bone Marrow-Derived Cells to Dermal Fibrosis

Caveolin-1 Regulates Chemokine Receptor 5-Mediated Contribution of Bone Marrow-Derived Cells to Dermal Fibrosis

In fibrotic diseases caveolin-1 underexpression in fibroblasts results in collagen overexpression and in monocytes leads to hypermigration. These profibrotic behaviors are blocked by the caveolin-1 scaffolding domain peptide (CSD) which compensates for caveolin-1 deficiency. Monocytes and fibroblast...

Full description

Bibliographic Details
Main Authors: Rebecca eLee, Beth ePerry, Jonathan eHeywood, Charles eReese, Michael eBonner, Corey eHatfield, Richard M Silver, Richard P Visconti, Stanley eHoffman, Elena eTourkina
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Pharmacology
Subjects:
Bleomycin
Lipodystrophy
Migration
Adipocyte
monocyte
scleroderma
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00140/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00140/full

Similar Items