Mitochondrial permeability transition and cell death: the role of cyclophilin D

Mitochondria serve as a powerhouse which provides near 90% of ATP necessary for cell life. However, recent studies provide strong evidence that mitochondria also play a central role in cell death. Irreversible mitochondrial permeability transition (mPT) at high conductance in response to oxidative...

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Bibliographic Details
Main Authors: Sabzali eJavadov, Andrey eKuznetsov
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00076/full