Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress

Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress

Compelling evidence from preclinical and clinical studies has shown that mild hypothermia is neuroprotective against ischemic stroke. We investigated the neuroprotective effect of post-risperidone (RIS) treatment against transient ischemic injury and its mechanisms in the gerbil brain. Transient isc...

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Bibliographic Details
Main Authors: Go Eun Yang, Hyun-Jin Tae, Tae-Kyeong Lee, Young Eun Park, Jeong Hwi Cho, Dae Won Kim, Joon Ha Park, Ji Hyeon Ahn, Sungwoo Ryoo, Young-Myeong Kim, Myoung Cheol Shin, Jun Hwi Cho, Choong-Hyun Lee, In Koo Hwang, Hui Jin, Moo-Ho Won, Jae-Chul Lee
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
ischemia/reperfusion
delayed neuronal death
antipsychotic drug
post-treatment
thermoregulation
5-HT<sub>2A</sub> antagonist
Online Access:https://www.mdpi.com/1422-0067/20/18/4621

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https://www.mdpi.com/1422-0067/20/18/4621

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