Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis

Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis

Abstract Background Despite increasing ethical standards for conducting animal research, death is still often used as an endpoint in mouse sepsis studies. Recently, the Murine Sepsis Score (MSS), Mouse Clinical Assessment Score for Sepsis (M-CASS), and Mouse Grimace Scale (MGS) were developed as sur...

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Bibliographic Details
Main Authors: Safiah H. C. Mai, Neha Sharma, Andrew C. Kwong, Dhruva J. Dwivedi, Momina Khan, Peter M. Grin, Alison E. Fox-Robichaud, Patricia C. Liaw
Format: Article
Language:English
Published: SpringerOpen 2018-07-01
Series:Intensive Care Medicine Experimental
Subjects:
Mouse model
Surrogate endpoints
Murine sepsis score
Mouse grimace scale
Mouse clinical assessment score for sepsis
Animal ethics
Online Access:http://link.springer.com/article/10.1186/s40635-018-0184-3

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http://link.springer.com/article/10.1186/s40635-018-0184-3

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