Effects of IFN-γ coding plasmid supplementation in the immune response and protection elicited by Trypanosoma cruzi attenuated parasites

Abstract Background Previous studies showed that a naturally attenuated strain from Trypanosoma cruzi triggers an immune response mainly related to a Th2-type profile. Albeit this, a strong protection against virulent challenge was obtained after priming mice with this attenuated strain. However, th...

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Bibliographic Details
Main Authors: Cecilia Pérez Brandán, Andrea C. Mesías, Cecilia Parodi, Rubén O. Cimino, Carolina Pérez Brandán, Patricio Diosque, Miguel Ángel Basombrío
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Infectious Diseases
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12879-017-2834-6