Exosomes containing miRNAs targeting HER2 synthesis and engineered to adhere to HER2 on tumor cells surface exhibit enhanced antitumor activity

Exosomes containing miRNAs targeting HER2 synthesis and engineered to adhere to HER2 on tumor cells surface exhibit enhanced antitumor activity

Abstract Background Exosomes are small, cellular membrane-derived vesicles with a diameter of 50–150 nm. Exosomes are considered ideal drug delivery systems with a wide range of applications in various diseases, including cancer. However, nonspecific delivery of therapeutic agents by exosomes in viv...

Full description

Bibliographic Details
Main Authors: Lei Wang, Xusha Zhou, Weixuan Zou, Yinglin Wu, Jing Zhao, Xiaoqing Chen, Grace Guoying Zhou
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Nanobiotechnology
Subjects:
Exosomes
HER2
miRNA
Targeted delivery
HER2-positive tumor
Intravenous injection
Online Access:http://link.springer.com/article/10.1186/s12951-020-00711-5

Internet

http://link.springer.com/article/10.1186/s12951-020-00711-5

Similar Items