Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth.

Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth.

MiR-21 is one of the most up-regulated miRNAs in multiple allergic diseases associated with eosinophilia and has been shown to positively correlate with eosinophil levels. Herein, we show that miR-21 is up-regulated during IL-5-driven eosinophil differentiation from progenitor cells in vitro. Target...

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Bibliographic Details
Main Authors: Thomas X Lu, Eun-Jin Lim, Svetlana Itskovich, John A Besse, Andrew J Plassard, Melissa K Mingler, Joelle A Rothenberg, Patricia C Fulkerson, Bruce J Aronow, Marc E Rothenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3606295?pdf=render

Internet

http://europepmc.org/articles/PMC3606295?pdf=render

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