Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model

Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model

Hypospadias and urethral stricture are common urological diseases which seriously affect voiding function and life quality of the patients, yet current clinical treatments often result in unsatisfactory clinical outcome with frequent complications. In vitro experiments confirmed that ICG-001 (a well...

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Main Authors: Kaile Zhang, Xiaolan Fang, Jingjing Zhu, Ranxing Yang, Ying Wang, Weixin Zhao, Xiumei Mo, Qiang Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
urethral stricture
nanoyarn
Wnt signaling
urethral reconstruction
urethroplasty
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00774/full
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spelling doaj-970447afbbeb472d9a09dc1d5314cfe92020-11-25T03:45:20ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-07-01810.3389/fbioe.2020.00774541391Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog ModelKaile Zhang0Xiaolan Fang1Jingjing Zhu2Ranxing Yang3Ying Wang4Weixin Zhao5Xiumei Mo6Qiang Fu7Department of Urology, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, ChinaDiagnostic Laboratory, Greenwood Genetic Center, Greenwood, SC, United StatesBiomaterials and Tissue Engineering Laboratory, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, ChinaDepartment of Urology, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Urology, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, ChinaWake Forest Institute for Regenerative Medicine, Winston-Salem, NC, United StatesBiomaterials and Tissue Engineering Laboratory, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, ChinaDepartment of Urology, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, ChinaHypospadias and urethral stricture are common urological diseases which seriously affect voiding function and life quality of the patients, yet current clinical treatments often result in unsatisfactory clinical outcome with frequent complications. In vitro experiments confirmed that ICG-001 (a well-established Wnt signaling inhibitor) could effectively suppress fibroblast proliferation and fibrotic protein expression. In this study, we applied a novel drug-delivering nanoyarn scaffold in urethroplasty in dog model, which continuously delivers ICG-001 during tissue reconstruction, and could effectively promote urethral recovery and resume fully functional urethra within 12 weeks. Such attempts are essential to the development of regenerative medicine for urological disorders and for broader clinical applications in human patients.https://www.frontiersin.org/article/10.3389/fbioe.2020.00774/fullurethral stricturenanoyarnWnt signalingurethral reconstructionurethroplasty
collection DOAJ
language English
format Article
sources DOAJ
author Kaile Zhang
Xiaolan Fang
Jingjing Zhu
Ranxing Yang
Ying Wang
Weixin Zhao
Xiumei Mo
Qiang Fu
spellingShingle Kaile Zhang
Xiaolan Fang
Jingjing Zhu
Ranxing Yang
Ying Wang
Weixin Zhao
Xiumei Mo
Qiang Fu
Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model
Frontiers in Bioengineering and Biotechnology
urethral stricture
nanoyarn
Wnt signaling
urethral reconstruction
urethroplasty
author_facet Kaile Zhang
Xiaolan Fang
Jingjing Zhu
Ranxing Yang
Ying Wang
Weixin Zhao
Xiumei Mo
Qiang Fu
author_sort Kaile Zhang
title Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model
title_short Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model
title_full Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model
title_fullStr Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model
title_full_unstemmed Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model
title_sort effective reconstruction of functional urethra promoted with icg-001 delivery using core-shell collagen/poly(llactide-co-caprolactone) [p(lla-cl)] nanoyarn-based scaffold: a study in dog model
publisher Frontiers Media S.A.
series Frontiers in Bioengineering and Biotechnology
issn 2296-4185
publishDate 2020-07-01
description Hypospadias and urethral stricture are common urological diseases which seriously affect voiding function and life quality of the patients, yet current clinical treatments often result in unsatisfactory clinical outcome with frequent complications. In vitro experiments confirmed that ICG-001 (a well-established Wnt signaling inhibitor) could effectively suppress fibroblast proliferation and fibrotic protein expression. In this study, we applied a novel drug-delivering nanoyarn scaffold in urethroplasty in dog model, which continuously delivers ICG-001 during tissue reconstruction, and could effectively promote urethral recovery and resume fully functional urethra within 12 weeks. Such attempts are essential to the development of regenerative medicine for urological disorders and for broader clinical applications in human patients.
topic urethral stricture
nanoyarn
Wnt signaling
urethral reconstruction
urethroplasty
url https://www.frontiersin.org/article/10.3389/fbioe.2020.00774/full
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AT ranxingyang effectivereconstructionoffunctionalurethrapromotedwithicg001deliveryusingcoreshellcollagenpolyllactidecocaprolactonepllaclnanoyarnbasedscaffoldastudyindogmodel
AT yingwang effectivereconstructionoffunctionalurethrapromotedwithicg001deliveryusingcoreshellcollagenpolyllactidecocaprolactonepllaclnanoyarnbasedscaffoldastudyindogmodel
AT weixinzhao effectivereconstructionoffunctionalurethrapromotedwithicg001deliveryusingcoreshellcollagenpolyllactidecocaprolactonepllaclnanoyarnbasedscaffoldastudyindogmodel
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