Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury

Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury

Limiting the development of secondary damage represents one of the major goals of neuroprotective therapies after spinal cord injury. Here, we demonstrate that specific JNK inhibition via a single intraperitoneal injection of the cell permeable peptide D-JNKI1 6 h after lesion improves locomotor rec...

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Bibliographic Details
Main Authors: Mariaelena Repici, Xiaoru Chen, Marie-Pierre Morel, Mohamed Doulazmi, Alessandra Sclip, Vidjeacoumary Cannaya, Pietro Veglianese, Rudolf Kraftsik, Jean Mariani, Tiziana Borsello, Isabelle Dusart
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Neurobiology of Disease
Subjects:
JNK
c-jun
Caspase-3
Spinal cord injury
Neuroprotection
Locomotor recovery
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611200085X

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http://www.sciencedirect.com/science/article/pii/S096999611200085X

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