Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling

Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling

Abstract Background Postoperative pain is a common phenomenon after surgery and is closely associated with the development of postoperative cognitive dysfunction (POCD). Persistent pain and systemic inflammation caused by surgery have been suggested as key factors for the development of POCD. Fracta...

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Bibliographic Details
Main Authors: Inja Cho, Jeong Min Kim, Eun Jung Kim, So Yeon Kim, Eun Hee Kam, Eunji Cheong, Minah Suh, Bon-Nyeo Koo
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Neuroinflammation
Subjects:
Postoperative pain
Postoperative cognitive dysfunction
CX3C chemokine receptor 1
Inflammation
GABA
Hippocampus
Online Access:https://doi.org/10.1186/s12974-021-02150-x

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