A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor
The LEAFY transcription factor is a master regulator of flower development in plants. Here the authors describe the structure of a LEAFY oligomerization domain and show that mutations that disrupt oligomerization alter its capacity to bind low affinity and poorly accessible target sites.
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| Language: | English |
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Nature Publishing Group
2016-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11222 |
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doaj-96d83391804042f59f93135fd8d1bacb2021-05-11T10:50:39ZengNature Publishing GroupNature Communications2041-17232016-04-017111210.1038/ncomms11222A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factorCamille Sayou0Max H. Nanao1Marc Jamin2David Posé3Emmanuel Thévenon4Laura Grégoire5Gabrielle Tichtinsky6Grégoire Denay7Felix Ott8Marta Peirats Llobet9Markus Schmid10Renaud Dumas11François Parcy12Laboratoire de Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS UMR5168, CEA/DRF/BIG, INRA UMR 1417, 17European Molecular Biology LaboratoryInstitut de Biologie Structurale CEA/DRF, CNRS, Université Grenoble Alpes, 71, avenue des MartyrsDepartment of Molecular Biology, Max Planck Institute for Developmental BiologyLaboratoire de Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS UMR5168, CEA/DRF/BIG, INRA UMR 1417, 17Laboratoire de Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS UMR5168, CEA/DRF/BIG, INRA UMR 1417, 17Laboratoire de Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS UMR5168, CEA/DRF/BIG, INRA UMR 1417, 17Laboratoire de Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS UMR5168, CEA/DRF/BIG, INRA UMR 1417, 17Department of Molecular Biology, Max Planck Institute for Developmental BiologyLaboratoire de Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS UMR5168, CEA/DRF/BIG, INRA UMR 1417, 17Department of Molecular Biology, Max Planck Institute for Developmental BiologyLaboratoire de Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS UMR5168, CEA/DRF/BIG, INRA UMR 1417, 17Laboratoire de Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS UMR5168, CEA/DRF/BIG, INRA UMR 1417, 17The LEAFY transcription factor is a master regulator of flower development in plants. Here the authors describe the structure of a LEAFY oligomerization domain and show that mutations that disrupt oligomerization alter its capacity to bind low affinity and poorly accessible target sites.https://doi.org/10.1038/ncomms11222 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Camille Sayou Max H. Nanao Marc Jamin David Posé Emmanuel Thévenon Laura Grégoire Gabrielle Tichtinsky Grégoire Denay Felix Ott Marta Peirats Llobet Markus Schmid Renaud Dumas François Parcy |
| spellingShingle |
Camille Sayou Max H. Nanao Marc Jamin David Posé Emmanuel Thévenon Laura Grégoire Gabrielle Tichtinsky Grégoire Denay Felix Ott Marta Peirats Llobet Markus Schmid Renaud Dumas François Parcy A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor Nature Communications |
| author_facet |
Camille Sayou Max H. Nanao Marc Jamin David Posé Emmanuel Thévenon Laura Grégoire Gabrielle Tichtinsky Grégoire Denay Felix Ott Marta Peirats Llobet Markus Schmid Renaud Dumas François Parcy |
| author_sort |
Camille Sayou |
| title |
A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor |
| title_short |
A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor |
| title_full |
A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor |
| title_fullStr |
A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor |
| title_full_unstemmed |
A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor |
| title_sort |
sam oligomerization domain shapes the genomic binding landscape of the leafy transcription factor |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-04-01 |
| description |
The LEAFY transcription factor is a master regulator of flower development in plants. Here the authors describe the structure of a LEAFY oligomerization domain and show that mutations that disrupt oligomerization alter its capacity to bind low affinity and poorly accessible target sites. |
| url |
https://doi.org/10.1038/ncomms11222 |
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