Measuring the effect of drug treatments on primary human CD8+ T cell activation and cytolytic potential

Summary: CD8+ T cells are key effector cells in adaptive immune responses against intracellular pathogens and cancer cells. Systemic drug treatments, like chemotherapy, may positively or negatively affect CD8+ T cell function. In this protocol, we describe robust and optimized ex vivo polyclonal act...

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Bibliographic Details
Main Authors: Helen Loo Yau, Daniel D. De Carvalho
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166721002562