Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

Bicyclic azetidine inhibitors are promising antimalarials that target the Plasmodium cytosolic phenylalanine tRNAsynthetase (cFRS). Here, Sharma et al. provide the biochemical and structural basis of its mechanism using co-crystal structure of PvcFRS with BRD1389.

Bibliographic Details
Main Authors: Manmohan Sharma, Nipun Malhotra, Manickam Yogavel, Karl Harlos, Bruno Melillo, Eamon Comer, Arthur Gonse, Suhel Parvez, Branko Mitasev, Francis G. Fang, Stuart L. Schreiber, Amit Sharma
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20478-5

Internet

https://doi.org/10.1038/s41467-020-20478-5

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