What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?

Intratumor heterogeneity is a feature of cancer that is associated with progression, treatment resistance, and recurrence. However, the mechanisms that allow diverse cancer cell lineages to coexist remain poorly understood. The storage effect is a coexistence mechanism that has been proposed to expl...

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Bibliographic Details
Main Authors: Anna K. Miller PhD, Joel S. Brown PhD, David Basanta PhD, Nancy Huntly PhD
Format: Article
Language:English
Published: SAGE Publishing 2020-07-01
Series:Cancer Control
Online Access:https://doi.org/10.1177/1073274820941968