The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter
Ca2+ entry into mitochondria is through the mitochondrial calcium uniporter complex (MCUcx), a Ca2+-selective channel composed of five subunit types. Two MCUcx subunits (MCU and EMRE) span the inner mitochondrial membrane, while three Ca2+-regulatory subunits (MICU1, MICU2, and MICU3) reside in the...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/69312 |