A theoretical entropy score as a single value to express inhibitor selectivity
<p>Abstract</p> <p>Background</p> <p>Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effects in the clinic, and for this reason compound selectivity is incre...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-04-01
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| Series: | BMC Bioinformatics |
| Online Access: | http://www.biomedcentral.com/1471-2105/12/94 |