Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli

Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli

Abstract Presynaptic CaV2.2 channels control calcium entry that triggers neurotransmitter release at both central and peripheral synapses. The Cacna1b gene encodes the α1-pore forming subunit of CaV2.2 channels. Distinct subsets of splice variants of CaV2.2 derived from cell-specific alternative spl...

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Bibliographic Details
Main Authors: Alexandra Bunda, Brianna LaCarubba, Melanie Bertolino, Marie Akiki, Kevin Bath, Javier Lopez-Soto, Diane Lipscombe, Arturo Andrade
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Molecular Brain
Subjects:
Calcium channels
Alternative splicing
Exploratory behavior
Anxiety
Medial entorhinal cortex
Dentate gyrus
Online Access:http://link.springer.com/article/10.1186/s13041-019-0500-1

Internet

http://link.springer.com/article/10.1186/s13041-019-0500-1

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