Granulocyte-Colony Stimulating Factor-Induced Neutrophil Recruitment Provides Opioid-Mediated Endogenous Anti-nociception in Female Mice With Oral Squamous Cell Carcinoma

Granulocyte-Colony Stimulating Factor-Induced Neutrophil Recruitment Provides Opioid-Mediated Endogenous Anti-nociception in Female Mice With Oral Squamous Cell Carcinoma

Oral cancer patients report severe function-induced pain; severity is greater in females. We hypothesize that a neutrophil-mediated endogenous analgesic mechanism is responsible for sex differences in nociception secondary to oral squamous cell carcinoma (SCC). Neutrophils isolated from the cancer-i...

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Bibliographic Details
Main Authors: Nicole N. Scheff, Robel G. Alemu, Richard Klares, Ian M. Wall, Stephen C. Yang, John C. Dolan, Brian L. Schmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
pain
neutrophils
anti-nociception
opioids
squamous cell carcinoma
sex differences
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00217/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00217/full

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