Putative bovine topological association domains and CTCF binding motifs can reduce the search space for causative regulatory variants of complex traits

Putative bovine topological association domains and CTCF binding motifs can reduce the search space for causative regulatory variants of complex traits

Abstract Background Topological association domains (TADs) are chromosomal domains characterised by frequent internal DNA-DNA interactions. The transcription factor CTCF binds to conserved DNA sequence patterns called CTCF binding motifs to either prohibit or facilitate chromosomal interactions. TAD...

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Bibliographic Details
Main Authors: Min Wang, Timothy P. Hancock, Amanda J. Chamberlain, Christy J. Vander Jagt, Jennie E. Pryce, Benjamin G. Cocks, Mike E. Goddard, Benjamin J. Hayes
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Genomics
Subjects:
Topological association domains
CTCF binding motifs
Allelic-specific expression
Allele-specific expression quantitative trail loci
Expression quantitative trail loci
Functional annotation
Online Access:http://link.springer.com/article/10.1186/s12864-018-4800-0

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http://link.springer.com/article/10.1186/s12864-018-4800-0

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