A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.

A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.

People who begin daily smoking at an early age are at greater risk of long-term nicotine addiction. We tested the hypothesis that associations between nicotinic acetylcholine receptor (nAChR) genetic variants and nicotine dependence assessed in adulthood will be stronger among smokers who began dail...

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Bibliographic Details
Main Authors: Robert B Weiss, Timothy B Baker, Dale S Cannon, Andrew von Niederhausern, Diane M Dunn, Nori Matsunami, Nanda A Singh, Lisa Baird, Hilary Coon, William M McMahon, Megan E Piper, Michael C Fiore, Mary Beth Scholand, John E Connett, Richard E Kanner, Lorise C Gahring, Scott W Rogers, John R Hoidal, Mark F Leppert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2442220?pdf=render

Internet

http://europepmc.org/articles/PMC2442220?pdf=render

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