FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult

FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult

Abstract Background Aberrant cell death induced by ischemic stress is implicated in the pathogenesis of ischemic diseases. Fas-associated factor 1 (FAF1) has been identified as a death-promoting protein. This study demonstrates that FAF1 functions in death signaling triggered by ischemic insult. Met...

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Bibliographic Details
Main Authors: Changsun Yu, Bok-seok Kim, Minyoung Park, Yun-Ju Do, Young-Yun Kong, Eunhee Kim
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Cell Communication and Signaling
Subjects:
FAF1
JNK1
Ischemic death
Retina
Online Access:http://link.springer.com/article/10.1186/s12964-018-0265-7

Internet

http://link.springer.com/article/10.1186/s12964-018-0265-7

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