P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases

P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases

Shortage of oxygen and nutrients in the brain induces the release of glutamate and ATP that can cause excitotoxicity and contribute to neuronal and glial damage. Our understanding of the mechanisms of ATP release and toxicity in cerebrovascular diseases is incomplete. This review aims at summarizing...

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Bibliographic Details
Main Authors: Abraham J. Cisneros-Mejorado, Alberto Pérez-Samartín, María Domercq, Rogelio O. Arellano, Miroslav Gottlieb, Friedrich Koch-Nolte, Carlos Matute
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
ATP
pannexin-1
ischemia
neuron
oligodendrocyte
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00092/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00092/full

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