mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

mTORC1 is a key mediator of drug resistance and also regulates autophagy. In this study, the authors demonstrate that cancer cells with acquired drug resistance exibit metabolic vulnerabilities mediated by high levels of mTORC1 and the consequent inhibition of autophagy.

Bibliographic Details
Main Authors: Niklas Gremke, Pierfrancesco Polo, Aaron Dort, Jean Schneikert, Sabrina Elmshäuser, Corinna Brehm, Ursula Klingmüller, Anna Schmitt, Hans Christian Reinhardt, Oleg Timofeev, Michael Wanzel, Thorsten Stiewe
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18504-7

Internet

https://doi.org/10.1038/s41467-020-18504-7

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