Biophysical Attributes of CpG Presentation Control TLR9 Signaling to Differentially Polarize Systemic Immune Responses

Biophysical Attributes of CpG Presentation Control TLR9 Signaling to Differentially Polarize Systemic Immune Responses

It is currently unknown whether and how mammalian pathogen recognition receptors (PRRs) respond to biophysical patterns of pathogen-associated molecular danger signals. Using synthetic pathogen-like particles (PLPs) that mimic physical properties of bacteria or large viruses, we have discovered that...

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Bibliographic Details
Main Authors: Jardin A. Leleux, Pallab Pradhan, Krishnendu Roy
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
TLR9
dendritic cells
PAMP
adjuvant density
vaccines
PLGA
immunotherapy
immune modulation
vaccine delivery
adjuvant delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317958

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http://www.sciencedirect.com/science/article/pii/S2211124716317958

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