Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer

Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer

Abstract Background Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the onset of chemo-resistance. Thus, novel therapeutic approaches are require...

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Bibliographic Details
Main Authors: Andy Göbel, Valentina M. Zinna, Stefania Dell’Endice, Nikolai Jaschke, Jan Dominik Kuhlmann, Pauline Wimberger, Tilman D. Rachner
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Cancer
Subjects:
Ovarian cancer
Statins
Amino-bisphosphonates
Apoptosis
Mevalonate pathway
Online Access:http://link.springer.com/article/10.1186/s12885-020-07164-x

Internet

http://link.springer.com/article/10.1186/s12885-020-07164-x

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