Late-stage trifluoromethylthiolation of benzylic C-H bonds

Late-stage trifluoromethylthiolation of benzylic C-H bonds

Fluoroalkylation of C-H bonds is a class of reaction highly sought after in medicinal chemistry. Here, the authors report a regioselective organophotoredox-catalyzed, trifluoromethylthiolation of benzylic C-H bonds for a wide variety of alkyl (hetero)arenes, and demonstrate its utility in continuous...

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Main Authors: Wentao Xu, Wenliang Wang, Tao Liu, Jin Xie, Chengjian Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12844-9
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spelling doaj-962eeabac799400c90079a016c0f307b2021-05-11T12:34:53ZengNature Publishing GroupNature Communications2041-17232019-10-011011810.1038/s41467-019-12844-9Late-stage trifluoromethylthiolation of benzylic C-H bondsWentao Xu0Wenliang Wang1Tao Liu2Jin Xie3Chengjian Zhu4State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityFluoroalkylation of C-H bonds is a class of reaction highly sought after in medicinal chemistry. Here, the authors report a regioselective organophotoredox-catalyzed, trifluoromethylthiolation of benzylic C-H bonds for a wide variety of alkyl (hetero)arenes, and demonstrate its utility in continuous flow.https://doi.org/10.1038/s41467-019-12844-9
collection DOAJ
language English
format Article
sources DOAJ
author Wentao Xu
Wenliang Wang
Tao Liu
Jin Xie
Chengjian Zhu
spellingShingle Wentao Xu
Wenliang Wang
Tao Liu
Jin Xie
Chengjian Zhu
Late-stage trifluoromethylthiolation of benzylic C-H bonds
Nature Communications
author_facet Wentao Xu
Wenliang Wang
Tao Liu
Jin Xie
Chengjian Zhu
author_sort Wentao Xu
title Late-stage trifluoromethylthiolation of benzylic C-H bonds
title_short Late-stage trifluoromethylthiolation of benzylic C-H bonds
title_full Late-stage trifluoromethylthiolation of benzylic C-H bonds
title_fullStr Late-stage trifluoromethylthiolation of benzylic C-H bonds
title_full_unstemmed Late-stage trifluoromethylthiolation of benzylic C-H bonds
title_sort late-stage trifluoromethylthiolation of benzylic c-h bonds
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description Fluoroalkylation of C-H bonds is a class of reaction highly sought after in medicinal chemistry. Here, the authors report a regioselective organophotoredox-catalyzed, trifluoromethylthiolation of benzylic C-H bonds for a wide variety of alkyl (hetero)arenes, and demonstrate its utility in continuous flow.
url https://doi.org/10.1038/s41467-019-12844-9
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AT wenliangwang latestagetrifluoromethylthiolationofbenzylicchbonds
AT taoliu latestagetrifluoromethylthiolationofbenzylicchbonds
AT jinxie latestagetrifluoromethylthiolationofbenzylicchbonds
AT chengjianzhu latestagetrifluoromethylthiolationofbenzylicchbonds
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