Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation

Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation

The human ether-a-go-go-related gene (HERG) potassium current (IHERG) has been shown to decrease in amplitude following stimulation with Gq protein-coupled receptors (GqRs), such as α1-adrenergic and M1-muscarinic receptors (α1R and M1R, respectively), at least partly via the reduction of membrane p...

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Bibliographic Details
Main Authors: Taeko Kubo, Wei-Guang Ding, Futoshi Toyoda, Yusuke Fujii, Mariko Omatsu-Kanbe, Hiroshi Matsuura
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Pharmacological Sciences
Subjects:
PI(4)P5-K
HERG channel
PI(4,5)P2
Gq protein-coupled receptors
Arrhythmia
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861314000218

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http://www.sciencedirect.com/science/article/pii/S1347861314000218

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