Fibroblast Growth Factor Type 2 (FGF2) Administration Attenuated the Clinical Manifestations of Preeclampsia in a Murine Model Induced by L-NAME

Fibroblast Growth Factor Type 2 (FGF2) Administration Attenuated the Clinical Manifestations of Preeclampsia in a Murine Model Induced by L-NAME

Background: In preeclampsia, a hypertensive disorder of pregnancy, the poor remodeling of spiral arteries leads to placental hypoperfusion and ischemia, provoking generalized maternal endothelial dysfunction and, in severe cases, death. Endothelial and placental remodeling is important for correct p...

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Bibliographic Details
Main Authors: Margarita L Martinez-Fierro, Gloria Patricia Hernadez-Delgadillo, Jose Feliciano Flores-Mendoza, Claudia Daniela Alvarez-Zuñiga, Martha Lizeth Diaz-Lozano, Ivan Delgado-Enciso, Viktor Javier Romero-Diaz, Adrian Lopez-Saucedo, Iram Pablo Rodriguez-Sanchez, Ivan Alberto Marino-Martinez, Idalia Garza-Veloz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
preeclampsia
FGF2
pregnancy hypertensive disorders
L-NAME
angiogenesis
rat model
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.663044/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.663044/full

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