Possible Insulinotropic Action of Apolipoprotein A–I Through the ABCA1/Cdc42/cAMP/PKA Pathway in MIN6 Cells

Possible Insulinotropic Action of Apolipoprotein A–I Through the ABCA1/Cdc42/cAMP/PKA Pathway in MIN6 Cells

Aims/Introduction: We studied the mechanisms for the possible insulinotropic action of apolipoprotein (Apo) A–I in mouse insulinoma (MIN6) cells.Materials and Methods: The effects of ApoA-I on cAMP production and glucose-stimulated insulin secretion (GSIS), and the dose dependency (ApoA-I at 5, 10,...

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Bibliographic Details
Main Authors: Koki Matsumura, Naoki Tamasawa, Makoto Daimon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Endocrinology
Subjects:
ApoA-I
HDL
insulin secretion
ABCA-1
Cdc42
cyclic AMP
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00645/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00645/full

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