CD44 in Ovarian Cancer Progression and Therapy Resistance—A Critical Role for STAT3

Despite significant progress in cancer therapy over the last decades, ovarian cancer remains the most lethal gynecologic malignancy worldwide with the five-year overall survival rate less than 30% due to frequent disease recurrence and chemoresistance. CD44 is a non-kinase transmembrane receptor tha...

Full description

Bibliographic Details
Main Authors: Antons Martincuks, Pei-Chuan Li, Qianqian Zhao, Chunyan Zhang, Yi-Jia Li, Hua Yu, Lorna Rodriguez-Rodriguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.589601/full