New 1H-Benzo[f]indazole-4,9-diones Conjugated with C-Protected Amino Acids and Other Derivatives: Synthesis and in Vitro Antiproliferative Evaluation

New 1H-Benzo[f]indazole-4,9-diones Conjugated with C-Protected Amino Acids and Other Derivatives: Synthesis and in Vitro Antiproliferative Evaluation

1H-Benzo[f]indazole-4,9-dione derivatives conjugated with C-protected amino acids (glycine, l-alanine, l-phenylalanine and l-glutamic acid) 6a–l were prepared by chemically modifying the prenyl substituent of 3-methyl-7-(4-methylpent-3-enyl)-1H-benzo[f]indazole-4,9-dione 2 through epoxidation, degra...

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Bibliographic Details
Main Authors: Aurora Molinari, Alfonso Oliva, Marlene Arismendi-Macuer, Leda Guzmán, Mauricio Fuentealba, Marcela Knox, Raúl Vinet, Arturo San Feliciano
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
1,4-naphthoquinone
1H-benzoindazole
pyrazole
amino acid
Online Access:http://www.mdpi.com/1420-3049/20/12/19809

Internet

http://www.mdpi.com/1420-3049/20/12/19809

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