Cerebral Protein Synthesis in a Knockin Mouse Model of the Fragile X Premutation

Cerebral Protein Synthesis in a Knockin Mouse Model of the Fragile X Premutation

The (CGG)n-repeat in the 5′-untranslated region of the fragile X mental retardation gene ( FMR1 ) gene is polymorphic and may become unstable on transmission to the next generation. In fragile X syndrome, CGG repeat lengths exceed 200, resulting in silencing of FMR1 and absence of its protein produc...

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Bibliographic Details
Main Authors: Mei Qin, Tianjian Huang, Zhonghua Liu, Michael Kader, Thomas Burlin, Zengyan Xia, Zachary Zeidler, Renate K. Hukema, Carolyn B. Smith
Format: Article
Language:English
Published: SAGE Publishing 2014-09-01
Series:ASN Neuro
Online Access:https://doi.org/10.1177/1759091414551957

Internet

https://doi.org/10.1177/1759091414551957

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