Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells.

Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells.

The identification of secreted factors that can selectively stimulate the generation of insulin producing beta-cells from stem and/or progenitor cells represent a significant step in the development of stem cell-based beta-cell replacement therapy. By elucidating the molecular mechanisms that regula...

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Bibliographic Details
Main Authors: Maria Oström, Kelly A Loffler, Sara Edfalk, Lars Selander, Ulf Dahl, Camillo Ricordi, Jongmin Jeon, Mayrin Correa-Medina, Juan Diez, Helena Edlund
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2475501?pdf=render

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http://europepmc.org/articles/PMC2475501?pdf=render

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