MicroRNA-sensitive oncolytic measles virus for chemovirotherapy of pancreatic cancer

MicroRNA-sensitive oncolytic measles virus for chemovirotherapy of pancreatic cancer

Advanced pancreatic cancer is characterized by few treatment options and poor outcomes. Oncolytic virotherapy and chemotherapy involve complementary pharmacodynamics and could synergize to improve therapeutic efficacy. Likewise, multimodality treatment may cause additional toxicity, and new agents h...

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Bibliographic Details
Main Authors: Hans Martin Singh, Mathias Felix Leber, Sascha Bossow, Christine E. Engeland, Jan Dessila, Christian Grossardt, Karim Zaoui, John C. Bell, Dirk Jäger, Christof von Kalle, Guy Ungerechts
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
chemovirotherapy
cytosine deaminase
fluorouracil
measles virus
microRNAs
miR-148a
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000656

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http://www.sciencedirect.com/science/article/pii/S2372770521000656

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