Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach

Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach

Ali S Abdelhameed, Mohamed W Attwa, Adnan A Kadi Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Kingdom of Saudi ArabiaCorrespondence: Ali S Abdelhameed Tel +966 1146 98314Fax +966 1146 76 220, Email asaber@ksu.edu.saBackground: Ensartinib (ESB) is a...

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Bibliographic Details
Main Authors:	Abdelhameed AS, Attwa MW, Kadi AA
Format:	Article
Language:	English
Published:	Dove Medical Press 2020-11-01
Series:	Drug Design, Development and Therapy
Subjects:	in vitro phase-i metabolites iminium intermediates epoxide intermediates human liver microsomes
Online Access:	https://www.dovepress.com/characterization-of-stable-and-reactive-metabolites-of-the-anticancer--peer-reviewed-article-DDDT

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