Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach

Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach

Ali S Abdelhameed, Mohamed W Attwa, Adnan A Kadi Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Kingdom of Saudi ArabiaCorrespondence: Ali S Abdelhameed Tel +966 1146 98314Fax +966 1146 76 220, Email asaber@ksu.edu.saBackground: Ensartinib (ESB) is a...

Full description

Bibliographic Details
Main Authors: Abdelhameed AS, Attwa MW, Kadi AA
Format: Article
Language:English
Published: Dove Medical Press 2020-11-01
Series:Drug Design, Development and Therapy
Subjects:
in vitro phase-i metabolites
iminium intermediates
epoxide intermediates
human liver microsomes
Online Access:https://www.dovepress.com/characterization-of-stable-and-reactive-metabolites-of-the-anticancer--peer-reviewed-article-DDDT

Internet

https://www.dovepress.com/characterization-of-stable-and-reactive-metabolites-of-the-anticancer--peer-reviewed-article-DDDT

Similar Items