Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing KATP channel

Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing KATP channel

Abstract Background Sulfonylureas (SUs) are widely prescribed for the treatment of type 2 diabetes (T2DM). Sulfonylurea receptors (SURs) are their main functional receptors. These receptors are also found in kidney, especially the tubular cells. However, the effects of SUs on renal proximal tubular...

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Bibliographic Details
Main Authors: Rui Zhang, Xiaojun Zhou, Xue Shen, Tianyue Xie, Chunmei Xu, Zhiwei Zou, Jianjun Dong, Lin Liao
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Molecular Medicine
Subjects:
Diabetes kidney disease
Proximal tubular epithelial cells
ATP-dependent potassium channel
Glibenclamide
Glimepiride
Gliclazide
Online Access:http://link.springer.com/article/10.1186/s10020-018-0042-5

Internet

http://link.springer.com/article/10.1186/s10020-018-0042-5

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