DQB1*06:02-Associated Pathogenic Anti-Myelin Autoimmunity in Multiple Sclerosis-like disease: Potential role of DQB1*06:02 as a disease predisposing allele.

DQB1*06:02-Associated Pathogenic Anti-Myelin Autoimmunity in Multiple Sclerosis-like disease: Potential role of DQB1*06:02 as a disease predisposing allele.

Susceptibility to Multiple Sclerosis (MS) has been linked mainly to the HLA-DRB1 locus, with the HLA-DR15 haplotype (DRB1*1501-DQA1*0102-DQB1*0602- DRB5*0101) dominating MS-risk in Caucasians. Although genes in the HLA-II region, particularly DRB1*1501, DQA1*0102-DQB1*0602, are in tight linkage dise...

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Bibliographic Details
Main Authors: Nathali eKaushansky, Avraham eBen-Nun
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Oncology
Subjects:
neuroimmunology
T-cells
MS/EAE
Antigens/Peptides/Epitopes
HLA-DR15-Tg mice.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00280/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00280/full

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