Low-dose post-transplant cyclophosphamide can mitigate GVHD and enhance the G-CSF/ATG induced GVHD protective activity and improve haploidentical transplant outcomes

Low-dose post-transplant cyclophosphamide can mitigate GVHD and enhance the G-CSF/ATG induced GVHD protective activity and improve haploidentical transplant outcomes

Use of high-dose, post-transplant cyclophosphamide (PTCy) results in low rates of graft-versus-host-disease (GVHD) and favorable immune reconstitution, although with higher rates of relapse and somewhat high rates of graft failure. We hypothesized that permissible dose reduction of PTCy might be fea...

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Bibliographic Details
Main Authors: Yu Wang, Ying-Jun Chang, Lu Chen, Lan-Ping Xu, Zhi-Lei Bian, Xiao-Hui Zhang, Chen-Hua Yan, Kai-Yan Liu, Xiao-Jun Huang
Format: Article
Language:English
Published: Taylor & Francis Group 2017-11-01
Series:OncoImmunology
Subjects:
antithymocyte globulin
graft-vs.-host disease
haploidentical stem cell transplantation
immune reconstitution
post-transplant cyclophosphamide
regulatory t cells
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1356152

Internet

http://dx.doi.org/10.1080/2162402X.2017.1356152

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