High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels.

High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels.

The eri-1 gene encodes a 3' exonuclease that can negatively regulate RNA interference via siRNase activity. High-dose siRNAs (hd-siRNAs) can enhance Eri-1 expression, which in return degrade siRNAs and greatly reduces RNAi efficiency. Here we report that hd-siRNAs induce mouse Eri-1 (meri-1) ex...

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Bibliographic Details
Main Authors: Yingnan Bian, Wei Zhou, Yingchun Zhao, Xiaoping Li, Wei Geng, Ruixin Hao, Qing Yang, Weida Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22039495/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22039495/?tool=EBI

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