The Invasive Region of Glioblastoma Defined by 5ALA Guided Surgery Has an Altered Cancer Stem Cell Marker Profile Compared to Central Tumour

The Invasive Region of Glioblastoma Defined by 5ALA Guided Surgery Has an Altered Cancer Stem Cell Marker Profile Compared to Central Tumour

Glioblastoma, a WHO grade IV astrocytoma, is a highly aggressive and heterogeneous tumour that infiltrates deeply into surrounding brain parenchyma, making complete surgical resection impossible. Despite chemo-radiotherapy, the residual cell population within brain parenchyma post-surgery causes ine...

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Bibliographic Details
Main Authors: Stuart J. Smith, Mohammed Diksin, Saachi Chhaya, Shwetha Sairam, Maria A. Estevez-Cebrero, Ruman Rahman
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:International Journal of Molecular Sciences
Subjects:
5ALA
intra-tumour heterogeneity
invasion
hypoxia
glioma stem cell
Online Access:https://www.mdpi.com/1422-0067/18/11/2452

Internet

https://www.mdpi.com/1422-0067/18/11/2452

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