Feasibility of Developing Radiotracers for MDM2: Synthesis and Preliminary Evaluation of an <sup>18</sup>F-Labeled Analogue of the MDM2 Inhibitor SP-141

Feasibility of Developing Radiotracers for MDM2: Synthesis and Preliminary Evaluation of an <sup>18</sup>F-Labeled Analogue of the MDM2 Inhibitor SP-141

Murine double minute 2 (MDM2), a negative regulator of the p53 tumor suppressor protein, is overexpressed in several human cancers. Herein we investigate the feasibility of developing <sup>18</sup>F-labeled compounds based on the small molecule inhibitor SP-141 for imaging tumor MDM2 exp...

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Bibliographic Details
Main Authors: Satish K. Chitneni, Zhengyuan Zhou, Brian E. Watts, Michael R. Zalutsky
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
MDM2
imaging
MDM2 inhibitor
fluorine-18
PET
radiotracer
Online Access:https://www.mdpi.com/1424-8247/14/4/358

Internet

https://www.mdpi.com/1424-8247/14/4/358

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