Novel Series of Methyl 3-(Substituted Benzoyl)-7-Substituted-2-Phenylindolizine-1-Carboxylates as Promising Anti-Inflammatory Agents: Molecular Modeling Studies

Novel Series of Methyl 3-(Substituted Benzoyl)-7-Substituted-2-Phenylindolizine-1-Carboxylates as Promising Anti-Inflammatory Agents: Molecular Modeling Studies

The cyclooxygenase-2 (COX-2) enzyme is considered to be an important target for developing novel anti-inflammatory agents. Selective COX-2 inhibitors offer the advantage of lower adverse effects that are commonly associated with non-selective COX inhibitors. In this work, a novel series of methyl 3-...

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Bibliographic Details
Main Authors: Katharigatta N. Venugopala, Omar H.A. Al-Attraqchi, Christophe Tratrat, Susanta K. Nayak, Mohamed A. Morsy, Bandar E. Aldhubiab, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Rashmi Venugopala, Michelyne Haroun, Meravanige B. Girish, Sandeep Chandrashekharappa, Osama I. Alwassil, Bharti Odhav
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Biomolecules
Subjects:
cox-2 inhibition
anti-inflammatory
indolizine derivatives
2-phenyl indolizine
molecular modeling
absorption
distribution
metabolism
excretion
toxicity [admet] prediction
Online Access:https://www.mdpi.com/2218-273X/9/11/661

Internet

https://www.mdpi.com/2218-273X/9/11/661

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